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Old drug rocks for advanced breast cancer.

Writer: Dr. Malwinder Singh SandhuDr. Malwinder Singh Sandhu

In 2020, a woman in her late 40s was diagnosed with stage 3 triple-positive breast cancer (ER, PR, HER2). She underwent chemotherapy and anti-HER2 therapy at that time. Unfortunately, her cancer returned in January 2024 with extensive liver metastasis and significantly elevated liver enzymes.

As the sole breadwinner for her family, following her husband's paralysis from a stroke and his recent passing, she faced substantial financial challenges in accessing further targeted therapy. Limited to chemotherapy or hormonal therapy, we decided on oral Capecitabine, an established treatment that allowed her to continue working and supporting her children.

Remarkably, this "old" drug delivered outstanding results. Within six months, her PET scan showed a radiologic complete response, and her liver function normalized after just four cycles.

This case highlights the continued efficacy of traditional treatments like chemotherapy in certain individuals, even as we advance towards newer targeted and immunotherapies. Old drug still rocks for advanced breast cancer




Liver metastasis on PET scan
PET showing liver metastasis

Liver metastasis on PET scan
PET showing liver metastasis

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CONSULTANT CLINICAL ONCOLOGIST 

DR MALWINDER SINGH SANDHU

PANTAI HOSPITAL KUALA LUMPUR

8, Jalan Bukit Pantai, Bangsar, 59100 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

+60 115 996 3508

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+60 115 996 3508

PANTAI HOSPITAL KLANG

Lot 5921, Persiaran Raja Muda Musa, Taman Radzi, 41200 Klang, Selangor

PANTAI HOSPITAL CHERAS

1, Jalan 1/96a, Taman Cheras Makmur, 56100 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

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